From 1802 to 1814, there was a decline in the number of applicants and in 1809 the teachers' seminary was temporarily closed. In 1807, the old building of the teachers' seminary on the Marktplatz was demolished. In 1823, the seminary was reopened as a Protestant teachers' seminary at Markgrafenstraße 48 under the direction of Wilhelm Heinrich Katz (1763-1851) and the pedagogical leadership of Wilhelm Stern (1792-1873), a student of Pestalozzi.
In 1829, a state ministry decree was issued that made attendance at the teachers' seminary compulsory for all Protestant prospective teachers in Baden. In the following year, the seminary was provided with its own building on the corner of Akademie- and Hans-Thoma-Straße with an adjoining boarding school. In 1865, the directorship of the seminary passed from Wilhelm Stern to Ferdinand Leutz.
In 1870, a new, larger seminary building was opened at Bismarckstraße 10, the current address of the main campus of the University of Education Karlsruhe. The neo-Renaissance style building was designed by the Karlsruhe architect, government building surveyor and university lecturer Heinrich Lang (1824 - 1893), a student of Heinrich Hübsch and Friedrich Eisenlohr. Lang was particularly famous for his outstanding achievements in designing school buildings, because he understood how to translate the requirements of the reformed educational system into functional architecture.
However, the increased number of young people interested in entering the teaching profession necessitated the opening of a second teachers' seminary as early as 1875, which was set up as a biconfessional teachers' seminary in view of the interdenominational school (Simultanschule) that was to be introduced as the standard school form in Baden the following year. In 1926, both teachers' seminaries as well as the female teachers' seminary (Prinzessin Wilhelm Stift), founded in 1873, were merged into the Karlsruhe Teachers' Training College. Unlike in Prussia, however, attending a teachers' training college was not yet considered completing a university programme, but rather a two-year course of training. (Source: https://stadtlexikon.karlsruhe.de).